Quiz 3 (Karp Ch. 4 & 5)  The quiz is due class time on Mon., Sept. 28.   Print out this sheet.  Go through the book carefully to answer questions.  Go to D2L to answer the questions. 

1. GLUT4 is an example of (p 158)
    a)  simple diffusion.
    b)  facilitated transporter.
    c)  active transporter.
    d)  cotransporter.

2. ABO blood types are determined by a saccharide attached to a protein or a ______________ of the red blood cell membrane (p130, look up glycolipid on p 127). 
    a)  phosphoglyceride
    b)  sphingolipid
    c)  cholesterol
    d)  triacylglcyerol 

3. Which of these integral proteins is an active transporter (p 159)?
    a)  Kv channel
    b)  GLUT4
    c)  Na/K ATPase
    d)  aquaporin

4. Epithelial cells within the intestine can absorb glucose against a concentration gradient by linking glucose transport with sodium transport, since sodium is much more concentrated outside the cell.  What term best describes this strategy (p 164)?
  a)  Antiport
  b)  Active transport
  c)  Cotransport
  d)  Importation

5. Acetocholine and norepinephrine are examples of (p 170):
    a)  glycoproteins.
    b)  integral proteins.
    c)  ion channels.
    d)  neurotransmitter. 

6. Acetyl CoA enters the TCA cycle by combining with (p 189 and Fig. 5.7):
    a) oxaloacetate.
    b) succinate.
    c) citrate.
    d) alpha-ketogluterate.

7. Which product of glycolysis is imported into the mitochondrion in order to feed the TCA cycle (p188 and Fig5.5)?  
    a) Pyruvate.
    b) Glucose 6-phosphate.  
    c) Acetyl CoA.
    d) Glyceraldehyde 3-phosphate.

8. Complex III (cytochrome bc₁) receives electrons directly from __________, which is a lipid soluble membrane molecule (p199 and  Fig 5.17). 
    a) ubiquinol
    b) cytochrome c
    c) NADH⁺
    d) FADH₂

9. Cytochrome c is a moveable peripheral proteins that is oxidized by complex (p200 and Fig 5.17):
    a)  I .
    b)  II .
    c)  III .
    d)  IV.

10. Where are ATP synthase complexes found in the mitochondrion (Fig 5.3 is a little confusing so see Fig 5.23)?
    a) On the outer membrane.
    b) In the intermembrane space.
    c) Attached to the cristae.
    d) Floating in the matrix.

Carefully read The Human Perspective: Defect in Ion Channels as a Cause of Inherited Disease on pp. 162-164 and answer the following. 
Caution: More than one answer may be true; I am looking for the answer indicated in the passage.  I reserve the right to be nit picky on these. 

11. Cystic fibrosis results from a defect in an ion channel of these kinds of cells:
    a)  Muscle.
    b)  Nerve.
    c)  Epithelial.
    d)  Sensory.  

12. The protein responsible for cystic fibrosis was given the name CFTR. The author indicates that it got this name because: 
    a) it was a member of the ABC transporter superfamily.
    b) it was a cyclic AMP-regulated chloride channel.
    c) this protein functions in the conductance of HCO- ions.
    d) the functioning of the protein was not clear.

13. According to the passage, why is cystic fibrosis a good candidate for gene therapy?
    a)  Seventy percent of the mutant alleles have the same genetic alteration.
    b)  CF heterozygotes may be protected from the effects of cholera.
    c)  Otherwise the prognosis for CF patients is poor.
    d)  The cells that cause the worst symptoms are in the epithelial tissue of the upper airtract.

14. The disadvantage of using an adenovirus to deliver the normal CFTR gene is that:
    a)  the andenovirus does not incorporate into the host chromsome.
    b)  the adenovirus is defective.
    c)  the adenovirus has not been effective.
    d)  the adenovirus can cause upper respiratory tract infections.

15. What destroys lung function in CF patients?
    a)  Build-up of mucus.
    b)  Chronic infections and inflammation.
    c)  Cholera bacteria.
    d)  Typhoid fever.